The inhibition of the SGLT2 in the proximal segments of the nephrons is an ideal intervention to inhibit the tubulo-glomerular feedback and mitigate glomerular hyperfiltration in subjects with obesity, thus representing an important breakthrough in reducing the consequences of this phenomenon, as well as a more accurate evaluation of anthropometric measurements (waist-to-height ratio or, when available, DEXA or segmental impedance). This evidence concerns the gene SLC5A2 and Obesity.