Natural PKC modulators, such as bryostatin-1 and prostratin, can induce HIV transcription in latently infected cells [39, 41, 46, 47, 50, 107] and are under investigation as therapeutic agents against other diseases, including cancer [108, 109], Alzheimer's disease [110–112], and multiple sclerosis [113]. This evidence concerns the gene PRRT2 and early-onset autosomal dominant Alzheimer disease.