Therefore, we performed the two-sample MR analyses to investigate the causal effect of DNA methylation related parameters (DNA methylation-estimated granulocyte proportions, DNA methylation Grim Age acceleration, DNA methylation Hannum age acceleration, DNA methylation-estimated plasminogen activator inhibitor-1 levels, DNA methylation PhenoAge acceleration) on different CVD events (myocardial infarction, pulmonary heart disease, atrial fibrillation, heart failure, hypertrophic cardiomyopathy, cardiomyopathy, coronary heart disease, ischemic heart diseases, valvular heart disease). This evidence concerns the gene SERPINE1 and coronary artery disorder.