Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary disease caused by loss-of-function mutations in the Htra1 gene, characterized by baldness, strokes, white matter lesions, and early-onset dementia (Tikka et al., 2014). Here, HTRA1 is linked to CARASIL.