LRRK2 and Parkinson disease: Genetic mouse models replicating PD often utilize genes considered to be causative, such as LRRK2, PRKN, and PINK1. Transgenic mouse models of these genes consistently exhibit motor dysfunction, and most of these models show age-related cognitive impairments (Magen and Chesselet, 2011; Magen et al., 2012; Pischedda et al., 2021; Dovonou et al., 2023).