DLGAP2 and type 1 diabetes mellitus: By conducting a causal mediation analysis, we identified significant indirect effects indicating that the risk conferred through exposure to maternal T1D may operate through changes to DNA methylation near DLGAP2. In contrast, only significant direct effects were identified for those with affected fathers, indicating that the increased risk conferred by exposure to paternal T1D operates through mechanisms other than DNA methylation near these regions.