DLGAP2 and type 1 diabetes mellitus: From the mediator model, family history of T1D was associated with DNA methylation at P < 0.05 for eight probes in the DLGAP2 region (Table 2), including cg02946697 and cg25674613 near CTD-2281E23.1; cg00565786 and cg27509052 near CTD-2281E23.2; cg19309499 near CTD-2281E23.3; and cg11192059, cg22763586, and cg27351978 near DLGAP2. Offspring of mothers with T1D had significantly increased methylation levels at each of these eight probes compared to children with no family history of T1D (all 95% CIs > 0).