It is worth noting that a previous PD study has shown that DASB binding changes in the striatum manifest with a different pattern than striatal dopamine transporter imaging (Roussakis et al., 2016), suggesting that non-specific striatal changes in our iRBD cohort are not simply the earliest manifestation of nigrostriatal dopaminergic denervation. Here, SLC6A3 is linked to Parkinson disease.