GLA and Fabry disease: In our study, 1 patient who was clinically diagnosed as having hypertensive nephrosclerosis had a pathogenic variant in GLA, which encodes alpha-galactosidase A. Fabry disease, which is an X-linked congenital disorder of glycosphingolipid catabolism, is caused by an alpha-galactosidase A deficiency or a deficiency in its activity.36