In the cohort from ADVOCATE with eGFR <20 ml/min per 1.73 m2, more than 80% of patients had myeloperoxidase-antineutrophil cytoplasmic antibody subtype,3 which is associated with more glomerulosclerosis, fibrosis, and worse long-term kidney function as compared to proteinase 3-antineutrophil cytoplasmic antibody.6 This evidence concerns the gene MPO and glomerulosclerosis.