Macroprolactinomas should be considered in any patient with neurological or ophthalmological signs and symptoms resulting from mass effect in the sellar region, such as headache or visual field changes with associated hypopituitarism.(13) Since a significant number of patients with acromegaly may also present HPRL, it is important to measure PRL in these patients.(5) This HPRL may be the result of a pituitary adenoma cosecreting PRL and growth hormone (GH),(14) as well as the compression of the pituitary stalk. This evidence concerns the gene PRL and hypopituitarism.