Although DRB1*08 was considerably lower (4.8% vs. 24.6%, P = 0.003), the allele frequencies of DRB1*04 and *10 were significantly higher in ACPA+ RA patients (22.2% vs. 8.9%, P = 0.048 and 23.8% vs. 8.9%, P = 0.030, respectively) (Table 3). This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.