A critical factor in the connection between HTN and OA, particularly knee OA, is interleukin 6, one of the most significant pro-inflammatory cytokines [29,30]. Inoue et al. studied community participants aged 30-86 years, and the prevalence of hypertension in the OA group was higher in both men and women, but the relationship with MetS was found only in women. Here, IL6 is linked to hypertensive disorder.