It commonly involves multiple genes such as ASPSCR1, SFPQ, PRCC, GRIPAP1, etc. Hence, the diversity of morphology observed in TFE3-rearranged RCC includes perivascular epithelioid cell neoplasms (PEComa) with a lack of PAX8 expression. The gene discussed is SFPQ; the disease is neoplasm with perivascular epithelioid cell differentiation.