A high concentration of INF-γ was found in patients, which may be attributed to the fact that INF-γ is a cytokine secreted by T cells in response to the immune and inflammatory systems and linked with rheumatoid arthritis.25 Also, C-reactive protein (CRP) is a sensitive marker of systemic inflammation in arthritis, where a high CRP was found in patients. This evidence concerns the gene CRP and rheumatoid arthritis.