The reason is that CRP is a protein produced by liver cells, and its concentration increases during inflammatory processes, where it is stimulated by pro-inflammatory cytokines, especially interleukin-6, which is the cytokine that causes arthritis.26 The patients also displayed a high ESR level, where its elevation indicates the presence of inflammation in the body, as inflammatory conditions lead to an increase in the number of proteins in the blood plasma. Here, IL6 is linked to arthritic joint disease.