A study showed that the level of LCN-2 was increased in patients with psoriasis and rheumatoid arthritis.9 It has also been found that serum LCN-2 levels can be used as an indicator of structural damage in rheumatoid arthritis (RA).10 In another study, LCN-2 levels were shown to be greater in RA patients compared to osteoarthritis individuals and normal controls.11 However, there is a need to study serum LCN-2 levels in patients with new-onset arthritis. The gene discussed is LCN2; the disease is osteoarthritis.