Additionally, Gaig et al. (24) found that patients carrying the HLA-DRB*10:01 allele were more likely to exhibit sleep abnormalities, medullary dysfunction, and autonomic nervous system disorders, while cognitive impairment was more associated with the absence of the HLA-DRB*10:01 allele. The gene discussed is HLA-DRB1; the disease is Cognitive impairment.