Additional tests for autoimmune encephalitis-related antibodies and central demyelinating antibodies, such as anti-NMDAR, anti-CASPR2, anti-LGI1, anti-AMPA, anti-GABAB, anti-GABAA, anti-DPPX, anti-mGluR1, anti-mGluR5, anti-GAD65, anti-MOG, anti-GFAP, and anti-AQP4 antibodies, yielded negative results in both patients. The gene discussed is GRM1; the disease is autoimmune encephalitis.