Considering the previously reported modulation of neuroplasticity after treatment with REL-1017 (13, 18, 19, 46), and the importance of neuroplasticity in ALS (47, 48) we evaluated the mRNA expression of PSD95 and SYN1 in end-stage spinal cord, two synaptic plasticity genes known to be altered in ALS (49). This evidence concerns the gene DLG4 and amyotrophic lateral sclerosis.