We examined several magnetic resonance imaging (MRI) measurements such as white matter hyperintensities, ventricular size, and brain atrophy, and two circulating biomarkers of brain injury, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), to gain a comprehensive view of the associations of 8 sphingolipid species with these measures. The gene discussed is NEFL; the disease is Brain atrophy.