Systolic BP > 90 mm Hg and RV dysfunction or myocardial necrosis defined by: RV dilation (apical 4-chamber RV diameter divided by LV diameter > 0.9), or RV systolic dysfunction on echocardiography, orRV dilation (4-chamber RV diameter divided by LV diameter > 0.9) on CT, or elevation of BNP (> 90 pg/mL), or N-terminal pro-BNP (> 500 pg/mL), orEKG changes (new complete or incomplete right bundle-branch block, anteroseptal ST elevation or depression, or anteroseptal T-wave inversion), or elevation of troponin I (> 0.4 ng/mL) or troponin T (> 0.1 ng/mL). The gene discussed is NPPB; the disease is Myocardial necrosis.