GTPBP2 and Kufor-Rakeb syndrome: The abnormal brain iron accumulation in the basal ganglia was also observed in other disorders, such as Kufor-Rakeb syndrome (KRS), Aceruloplasminemia (ACEP), Spastic paraplegia 35 (SPG35), and Jaberi-Elahi syndrome (JABELS), which were caused by mutated ATP13A2 [16], CP [17], FA2H [18], GTPBP2 [19], respectively.