In fact, TRPM3 activity by pregnenolone sulfate (PregS), a TRPM3 agonist, in NK cells from post-COVID-19 condition patients mimicked the results from ME/CFS patients, while a significant difference was found between post-COVID-19 condition patients and healthy controls (HC). Here, TRPM3 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.