Interestingly, in colon cancer, stem-like cells secrete EVs containing RNA that induce interleukin-1B (IL-1B) expression and activate an NF-κB signaling axis to increase neutrophil granulocyte lifespan and polarization of TANs to a pro-tumorigenic phenotype that promotes tumorigenesis of colon cancer (130). Here, NFKB1 is linked to malignant colon neoplasm.