BM-MSCs grown under hypoxic conditions secrete exosomes containing miRNAs such as miR-193a-3p, miR-210-3p, and miR-5100 that when internalized by NSCLC cells activated the STAT3 pathway, leading to the upregulation of mesenchymal markers such as Vimentin, Twist, and SNAIL and promoted metastasis (109). Here, VIM is linked to non-small cell lung carcinoma.