STAT3 and non-small cell lung carcinoma: BM-MSCs grown under hypoxic conditions secrete exosomes containing miRNAs such as miR-193a-3p, miR-210-3p, and miR-5100 that when internalized by NSCLC cells activated the STAT3 pathway, leading to the upregulation of mesenchymal markers such as Vimentin, Twist, and SNAIL and promoted metastasis (109).