In contrast, silencing of SAMHD1 in WS cells or in cells expressing the WRN mutant conferring a defect in the long-range end-resection (WRN S1133A) induced a milder improvement in the extinction of DSBs or a defective DSBs repair as apparent at 4gh of recovery in the WRNS1133Amutant (Figure 1e; bottom). Here, WRN is linked to Werner syndrome.