Diffuse cytoplasmic staining of Nogo-A was observed in OLCs in all samples (Fig. 5, Supplementary Figs. 6 and 8 and Supplementary Table 3); positive staining of Nogo-A was also observed in astrocytic component of RGNT, white matter oligodendrocytes, parts of neurons and the background myelin sheaths.47,48 Tumour cells showed negative staining for ENPP6 and MBP in all samples analysed (Supplementary Fig. 9). The gene discussed is ENPP6; the disease is neoplasm.