In contrast, our findings show nearly universal staining of pan-oligodendrocyte lineage markers OLIG2 and SOX10, OPC makers PDGFRA and NG2 and developing oligodendrocyte marker Nogo-A in the tumour cells of DNET, MGNT and RGNT samples and an enrichment of OPC signature in DNET transcriptomes. The gene discussed is RTN4; the disease is neoplasm.