RBFOX3 and neoplasm: Along the path of OPC differentiation into postmitotic, pre-MO and MO, early oligodendrocyte lineage cells are supported by the neuronal activities for proliferation and differentiation.52,53 The scattered neuronal cell body (NeuN staining) and the pervasive spread of axons (NF staining) and dendrites (MAP-2 staining) suggest that in analogy to OPC development, tumour cells in at least subsets of LGNTs may also be supported by neuronal activities, which may constitute a microenvironment niche involved in the maintenance of OPC-like malignant cells.