CA9 and cancer: According to the results obtained from molecular docking studies,all compounds investigated in the current study exhibited higher bindingaffinities to hCA I and hCA II compared to the reference drug, acetazolamide.CA IX and XII are overexpressed in many cancers, meaning there isa much higher concentration compared to normal cells.95 This overexpression is linked to tumor growth, spread,and worse patient outcomes.96 Therefore,they are considered potential targets for cancer drugs.