This includes a case of angiomatoid fibrous histiocytoma with EWSR1-CREM fusion, an angiocentric glioma with MYB-QKI fusion, a glioma with MYCN amplification, two patients with non-canonical IDH mutations (both with IDH1 R132S), and a patient with a KRAS mutation (Table 1). The gene discussed is IDH1; the disease is central nervous system cancer.