The number of IL-6Rα positive cells in P.g-BPH group (5.74-fold), and the number of gp130 positive cells in LPS-BPH group (3.57-fold) and P.g-BPH group (4.47-fold) were significantly higher than those in control group (P < 0.05 or P < 0.001). This evidence concerns the gene IL6R and benign prostatic hyperplasia.