It was found that 14 genes with multiple mutations (n ≥ 3) were unique to metastatic tumors, including DYDC1, KRTAP5-4, RECQL, FAM92B, ABCA8, PRAMEF12, NBPF10, IGFN1, BUB1, SMC6, STAT4, EZH2, RP1L1, and ATRX. This evidence concerns the gene BUB1 and metastatic neoplasm.