There was a significant difference between EZH2 G553C genotype lung cancer brain metastasis and lung cancer population (p = 0.045) (Table 1), that is, there was a significant difference in G allele frequency between lung cancer brain metastasis and lung cancer (p = 0.031), The risk of lung cancer brain metastasis increased by 2.1241 times in G allele carriers OR = 2.124, 95% CI [1.061-4.254] (Table 2). The gene discussed is EZH2; the disease is metastasis.