Deleterious mutations in genes regulating acrosome biogenesis, such as Spermatogenesis Associated-16 (SPATA16), Dpy-19 Like-2 (DPY19L2), Zona Pellucida Binding Protein-1 (ZPBP1) and the Coiled-Coil Domain-Containing-62 (CCDC62), typically lead to globozoospermia, defined by sperm with a round-shaped head, and an atrophied, misplaced, or virtually absent acrosome, as shown by studies in consanguineous and non-consanguineous human populations [104–106]. The gene discussed is CCDC62; the disease is Globozoospermia.