Specifically, 3 of the 7 pathogenic/pathogenic CNVs were known to cause syndromes, including 15q11-q13 microduplication syndrome (OMIM#608363), 2q31.1-q31.2 microdeletion syndrome (OMIM#142989), and Xp11.23 microduplication syndrome (OMIM#300801), while 3 were rare pathogenic CNV syndromes, each of which spanned dosage-sensitive genes related to NDD, including 12p13.33 microdeletion syndrome (CACNA1C involved), 6q25.3 microdeletion syndrome (ERMARD involved), and 19p13.2 microdeletion syndrome (CACNA1A involved). This evidence concerns the gene CACNA1A and Neurodevelopmental delay.