Taken together, our findings provide novel insight into the role and regulatory mechanisms of the natural targeting blocker BA of EGFR and a more thorough understanding of the molecular mechanisms by which BA and its combination induce autophagy-related cell death, which will ensure its eventual translation into clinical application and may identify a new therapeutic approach for wt-EGFR NSCLC patients. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.