In conclusion, our findings demonstrated that the FGF pathway facilitates glycolysis by altering the LDHA/LDHB ratio through the activation of LDHA and suppression of LDHB in a STAT1-dependent manner in PCa cells, which enables PCa cells to fully utilize glycolysis to meet cell proliferation needs (Fig. 8G). This evidence concerns the gene LDHB and posterior cortical atrophy.