Heat shock protein family A (HSP70) member 8 (HSPA8) in mulberry bark-derived nanovesicles binds to the AHR and selectively activates constitutive photomorphogenesis 9 (COP9)/COPS8 in the intestinal epithelium, thereby protecting the intestinal epithelium, which is essential for the prevention of DSS-induced colitis in mice [88]. The gene discussed is COPS8; the disease is colitis.