Then we performed the analysis of immune infiltrates on TIMER 2.0 database, the results showed that the LTF expression in GBM was negatively correlated with tumor purity and positively correlated with CD4 + effector memory T cells, macrophages, neutrophils and cancer associated fibroblast, suggesting the LTF may also indirectly regulate GBM by immune infiltrates. The gene discussed is CD4; the disease is cancer.