Recently, an increased focus has been on elucidating the LTF in cancer, researchers have reported that LTF gene behaves like a tumor suppressor gene in diverse tumors, such as renal cancer, prostate cancer and gastric cancer et al.(Ni et al. 2020; Gołąbek et al. 2022; Zhao et al. 2021; Luo et al. 2015; Yi et al. 2006; Liu et al. 2022). This evidence concerns the gene LTF and Familial prostate cancer.