Among which, SAA1, SAA2(Rosa et al. 2017; Sun and Ye 2016; Takehara et al. 2020; Zhang et al. 2021), HP(Oh et al. 2023), NAMPT(Bi and Che 2010; Gasparrini and Audrito 2022; Wei et al. 2022), CHI3L1 and CHI3L2 (Libreros et al. 2013; Pusztai et al. 2019) have been reported to act as tumor promoters in multiple cancers including lung cancer, breast cancer and ovarian cancer. The gene discussed is CHI3L2; the disease is cancer.