Among which, SAA1, SAA2(Rosa et al. 2017; Sun and Ye 2016; Takehara et al. 2020; Zhang et al. 2021), HP(Oh et al. 2023), NAMPT(Bi and Che 2010; Gasparrini and Audrito 2022; Wei et al. 2022), CHI3L1 and CHI3L2 (Libreros et al. 2013; Pusztai et al. 2019) have been reported to act as tumor promoters in multiple cancers including lung cancer, breast cancer and ovarian cancer. This evidence concerns the gene CHI3L2 and neoplasm.