RIPK1 and prostate carcinoma: Necrostatin-1 blocks RIPK1 kinase activity by interacting with an essential structure for the death domain receptor engagement T loop and blocking RIPK1 kinase activity.1180 In addition, necrostatin-1 analogs were also effective in inducing necrotic cell death.1181,1182 BI2536, a small molecule inhibitor of mitotic kinase polo-like kinase 1, induces necroptotic cell death in prostate cancer cells.1183