Overexpression of ZEB2 blocks E-cadherin protein-mediated intercellular adhesion and promotes tumor cell metastasis.671 ZEB2 promotes the migration and invasion of breast cancer,672 bladder cancer, ovarian cancer, stomach cancer, CRC,673 OSCC,674 and pancreatic cancer.667. The gene discussed is ZEB2; the disease is familial pancreatic carcinoma.