AKT belongs to the serine/threonine kinases family,343 which contains three isoforms with highly similar structures: AKT1, AKT2, and AKT3, making the development of their isoform-specific inhibitors challenging.346 Meaningfully, tumors with AKT1 mutations and AKT2 and AKT3 amplifications are highly sensitive to AKT inhibitors, while many PIK3CA mutant cancer cells were considerably less dependent on AKT,1003 which guides the rational use of AKT inhibitors. The gene discussed is PIK3CA; the disease is cancer.