Antiangiogenic agents can reshape the immune TME, while immune checkpoint inhibitors can downregulate vascular endothelial growth factor expression and alleviate hypoxic conditions to combat angiogenesis.1096 Moreover, withdrawal of antiangiogenic drugs may result in tumor growth and metastasis, and the strategy to prevent this rebound needs to be developed.1097 In conclusion, tumor angiogenesis is essential for tumor growth. The gene discussed is VEGFA; the disease is neoplasm.