CASP8 and cancer: The proapoptotic death receptors bind to ligands and then trimerize and aggregate within the cell membrane, subsequently recruiting adapter proteins such as FADD, caspase 8 and/or caspase 10 to form the death-inducing signaling complex, which activates the initiator caspase 8, which in turn induces the activation of the effector caspases such as caspase 3, 6, and 7, and apoptosis.463,467 Consequently, the potential strategy for cancer therapy is targeting the proapoptotic and antiapoptotic proteins to induce apoptosis.468