HK2 and hepatocellular carcinoma: For example, the negative effect of HK2 on OS is observed in HCC, gastric cancer, and CRC patients.801 HK2 expression is correlated with advanced-stage and high-grade ovarian cancer.798 HK2 downregulation inhibits tumor occurrence.802 Thus, HK2 is a meaningful prognostic tumor biomarker and a potential tumor treatment target.