NFKB1 and Familial prostate cancer: Specific PTEN deficiency in mouse prostate cancer tissues leads to precancerous lesion development with extensive senescence and SASP.867,870 In general, SASP factors regulated by NF-kB have tumor-suppressive, immunosurveillance effects, while SASP factors regulated by signal transducer and activator of transcription 3 (STAT3) have tumor-promoting and immunosuppressive effects.867