NFKB1 and cancer: Activated NF-κB in cancer cells initiates and maintains the TME by upregulating chemokines that recruit immune response cells, inflammatory cells, and progenitors of cancer-associated fibroblasts.769 In addition, NF-κB regulates the EMT transition through the induction of EMT transcription factors.770,771 In conclusion, NF-κB is a prognostic biomarker of tumor inflammation in cancer.