IDH1 and central nervous system cancer: Some special genomic biomarkers, including miRNA, lncRNA, and circRNA, have been discovered by RNA sequencing.102 For example, isocitrate dehydrogenase (IDH) mutation which is a good prognostic biomarker for glioma, and nuclear cyclooxygenase 2 combined with HER2 which serve as potential biomarkers for the diagnosis and prognosis of CRC, are identified by RNA sequencing.102