BCL2 and neoplasm: Shikonin analogs such as deoxyshikonin, acetylshikonin, isobutyrylshikonin, beta-dimethylacrylshikonin, isovalerylshikonin, and alpha-methyl-n butylshikonin are able to induce necrosis, thus overcoming tumor resistances which are mediated by the resistance factors such as P-gp, BCL-2 and BCL-XL, MRP1, and BCRP1.1188 Obatoclax (GX15-070) is an indole bipyrrole compound antagonizing BCL-2, BCL-XL, BCL-W, and MCL1, which triggers necrotizing cell death by promoting necrosomes on autophagosomal membranes.