The combination of periodin (POSTN) with CA15-3 and CEA for the diagnosis of breast cancer can improve the diagnostic performance of CA15-3 and CEA.14 For CRC, the detection of hemoglobin using fecal immunochemical testing in combination with transferrin in stool improves the diagnostic accuracy for CRC.51 The combination of various diagnosis strategies with biomarkers could result in an easier, faster, more accurate, and more specific diagnosis of cancer. The gene discussed is CEACAM5; the disease is breast carcinoma.