LMNB1 and cancer: Lamin regulates nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genomic stability, differentiation, and tissue-specific functions by binding to a variety of nuclear protein complexes.871 Lamin B1 is essential for the regulation of normal organogenesis and organism survival.872 Lamin B1 knockdown triggers the formation of H3K27me3-enriched mesas and DNA hypomethylation regions overlapping with lamin B1-associated domains in cancer and accelerates the replicative and oncogene-induced senescence.