MUC5AC and ovarian cancer: CA125, a highly glycosylated mucin, is originally discovered in a monoclonal antibody OC125 screening against the ovarian cancer cell line OVCA433.232,233 Thus, CA125 has become one of the most important biomarkers for monitoring epithelial ovarian cancer, and its sensitivity in the diagnosis of epithelial ovarian cancer reaches ~70%.234 The key role of CA125 in the prognosis of ovarian cancer patients has also been recognized.