The transmembrane glucose transporter protein 1 (GLUT1, also known as SLC2A1) is the major glucose transporter protein, and GLUT1 expression is significantly upregulated in tumor cells.784 The crystal structure of human GLUT1 was first reported in 2014,785 and the expression of GLUT1 is regulated by various signaling pathways. The gene discussed is SLC2A1; the disease is neoplasm.