NFKB1 and breast cancer: As a key regulator of inflammation,765 NF-κB is activated in various hematological and solid tumors and is closely associated with tumor development.766 A meta-analysis of 44 studies with a total of 4418 patients has revealed that NF-κB expression is connected to poor 3-year and 10-year OS in solid tumors.767 NF-κB level is significantly associated with large tumor size and high tumor grade in breast cancer patients.768 NF-κB also plays an important role in the TME.