CDH3 and neoplasm: Cadherins are a superfamily of at least 80 specific types of adhesion molecules characterized by the ability to form calcium-dependent intercellular homophilic bonds,607 which are involved in the regulation of tumor cell recognition, tumor suppression, and tissue morphogenesis.608 Common family members include Epithelial (E)-cadherin, Neuronal (N)-cadherin, and Placental (P)-cadherin.609 E-cadherin, a homophilic cell-cell adhesion molecule,610 is a type I cadherin expressed in epithelial cells.