The hexokinases family has five isoforms in mammals including hexokinase 1–4 (HK1, HK2, HK3, HK4), and HKDC1.798 HK2 is the most active isozyme of the hexokinase family.799 In addition to being expressed in the muscle and heart,798 HK2 has been evaluated in various cancers, and is induced solely or synergistically by HIF-1 and MYC.800 An analysis of 21 studies with 2532 patients has revealed that HK2 overexpression is significantly associated with worse OS and PFS in solid tumors. Here, HK1 is linked to cancer.