FGF2 and neoplasm: In tumors, FGF is essential for vascular endothelial integrity, angiogenesis, tumor proliferation, survival, and metastasis.425,426 Notably, abnormal FGF signaling accelerates tumor proliferation by promoting tumor angiogenesis.422 For example, the elevated level of FGF2 in prostate cancer induces neovascularization to boost tumor growth.427 The increased angiogenesis induced by FGF1 amplification in high-grade serous ovarian cancer leads to reduced OS in patients, suggesting that FGF1 is a prognostic biomarker for ovarian cancer.428