Some special genomic biomarkers, including miRNA, lncRNA, and circRNA, have been discovered by RNA sequencing.102 For example, isocitrate dehydrogenase (IDH) mutation which is a good prognostic biomarker for glioma, and nuclear cyclooxygenase 2 combined with HER2 which serve as potential biomarkers for the diagnosis and prognosis of CRC, are identified by RNA sequencing.102. This evidence concerns the gene IDH2 and central nervous system cancer.