GLS and cancer: Similarly, amino acids, especially glutamine, participate in various cellular processes in cancer progression, which provide a major source of energy, cell component building blocks, and redox homeostasis, thereby providing a scientific rationale for targeting their metabolism for cancer treatment.1289 Anticancer drug candidates against glutamine metabolism and closely linking metabolic networks, such as glutamine transporter SLC1A5, glutaminase (GLS), and aminotransferase, have shown promising effects in cancer treatment (Fig. 6).