CAM17.1 is a mucin with high specificity for the digestive system, such as the pancreas, colon, small intestine, and biliary tract.286 Several studies revealed that CAM17.1 is particularly overexpressed in pancreatic cancer with a serum cut-off value is 39 U/L.287 CAM17.1 has a sensitivity of 86% for the diagnosis of pancreatic cancer, and a higher sensitivity of 89% in patients without jaundice.286 These findings suggested that CAM17.1 is a potential biomarker for pancreatic cancer diagnosis, which triggers the need for further study. This evidence concerns the gene MUC5AC and pancreatic neoplasm.