PIK3CA and cancer: To date, drugs or compounds targeting the apoptosis modulator BCL-2/BCL-XL, PI3K-AKT-mTOR, BET, tyrosine kinases, and GLS have exhibited promising effects on the clearance of senescent cells.865,1370 Apoptosis resistance is a feature shared by both cancer and senescent cells; thus, blocking antiapoptotic proteins could selectively eliminate senescent cells.