The RIPK3 expression is significantly reduced in AML patients,579,580 which is consistent with the high methylation level near the transcriptional start site of RIPK3.581 RIPK3 deficiency promotes leukemogenesis by enhancing the accumulation of leukemia-initiating cells, and hinders myeloid differentiation through reducing cell death and IL-1β production.579,580 In addition, RIPK3 expression plays an important role in solid tumors. This evidence concerns the gene RIPK3 and leukemia.