HGF promotes HCC migration and invasion, and is positively correlated with HCC metastasis.692 HGF has been observed to be an independent blood-based predictive biomarker and primary diagnostic marker in ovarian cancer patients.693 Moreover, HGF/c-MET can be used as a prognostic biomarker in various hematologic tumors, such as B-cell lymphoma, T and natural killer (NK) cell lymphoma, and Hodgkin lymphoma.694. This evidence concerns the gene HGF and hepatocellular carcinoma.