Squamous cell carcinoma antigen (SCCA), a tumor-specific antigen, was first isolated from cervical SCC tissue by Kato and Torigoe in the 1970s.165 Initially, SCCA was used as a tumor biomarker for cervical cancer, and it has a high independent diagnostic value in cervical cancer.166 The serum level of SCCA correlates with the stage, the degree of invasion, recurrence, and the progression of cervical SCC.159 Cervical cancer patients with a high-level of pretreatment serum SCCA exhibit a higher risk for death than patients with low serum SCCA. This evidence concerns the gene SERPINB3 and cervical carcinoma.