The PRMT1 inhibitor TC-E increases the apoptosis sensitivity of cancer cells by regulating the NF-κB pathway.862 Rapamycin, an inhibitor of mTOR, has been found to reduce SASP by inhibiting mTOR and to limit the growth-promoting effect of senescent bystander fibroblasts on prostate cancers.1384,1385. This evidence concerns the gene NFKB1 and Familial prostate cancer.