A high level of lamin B1 expression predicts poor OS and DFS for cancer patients.875 Lamin B1 is overexpressed and facilitates cell proliferation and metastasis in HCC, and increased lamin B1 expression indicates a dismal prognosis and immunotherapy response in HCC.876 Besides, lamin B1 has been proposed as a prognostic senescence biomarker in ccRCC877 and lung adenocarcinoma.878 To summarize, lamin B1 loss is a senescence-associated biomarker. This evidence concerns the gene LMNB1 and cancer.