Consistent with human CRC scRNA-seq data that CD8+ T cell infiltration in tumors is positively associated with the DEPDC5 level in CD8+ T cells (Fig. 1b), we found that there were small numbers of CD8+ T cells in tumors from Depdc5tko mice compared with Depdc5ncl mice (Fig. 7d, e). Here, CD8A is linked to colorectal carcinoma.