We also noticed that another epilepsy patient with a frameshift mutation (L1200R frameshift) in DEPDC5 also had a recurrent infection and reduced blood CD8+ T cell numbers compared with healthy donors (data not shown), suggesting that in addition to causing epilepsy, loss of DEPDC5-mediated GATOR1 function may impair CD8+ T cell homeostasis. Here, DEPDC5 is linked to epilepsy.