This may relate to the antiproliferative effect of Cel in a wide range of human cancer cells, including glioma, breast cancer, and head and neck carcinoma.39 Boridy et al. found that Cel can target the proteotoxic stress responses by inhibiting the expression of heat-shock protein 90 (HSP90) and promote cell death through the ROS/c-Jun N-terminal kinase (JNK) pathway in human glioblastoma cells.40 Here, MAPK8 is linked to central nervous system cancer.