MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer's disease (AD) is a neurodegenerative disorder with multiple aetiologies that is characterized by pathophysiological manifestations such as dysfunction of the neurovascular unit [[1], [2], [3], [4]], loss of memory function [5], tau-related lesions in neurons termed neurofibrillary tangles [6,7], synaptic degeneration [8,9], neuroinflammation [[10], [11], [12], [13]], metabolic perturbation [14,15], neuronal cell death [16] and, most importantly, aggregation of amyloid beta (Aβ) [17].