NLRP3 and cryopyrin-associated periodic syndrome: Variants in residues surrounding this site have also been linked to cryopyrin-associated periodic syndrome (CAPS), a group of autoinflammatory diseases characterized by IL-1β-mediated inflammation, and S295A mutation phenocopied these variants in vitro (24), suggesting that this phosphorylation event could be crucial for NLRP3 inhibition.