Interestingly, a mutation at Tyr 861 (Tyr -> Cys) in NLRP3 has been reported as causative for neonatal-onset multisystem inflammatory disease (NOMID), a form of CAPS (33), further supporting the hypothesis that phosphorylation at this site is necessary for restraint of inflammasome activation. The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.