Variants in residues surrounding this site have also been linked to cryopyrin-associated periodic syndrome (CAPS), a group of autoinflammatory diseases characterized by IL-1β-mediated inflammation, and S295A mutation phenocopied these variants in vitro (24), suggesting that this phosphorylation event could be crucial for NLRP3 inhibition. The gene discussed is IL1B; the disease is cryopyrin-associated periodic syndrome.