It is associated with several mechanisms such as the presence of heterogeneous telomere lengths, colocalization of telomeres with promyelocytic leukemia nuclear bodies in the ALT-associated promyelocytic leukemia nuclear bodies (called APB), extrachromosomal telomeric repeats such as C-circles, and frequent exchanges between sister telomeres known as T-SCEs. Here, GPT is linked to acute promyelocytic leukemia.