DMD and Marfan syndrome: As the result of our study, over-expression of FBN1 induced DMD, however, patients with Marfan syndrome (MFS), which is caused by an FBN1 mutation as well as Fbn1-deficient mice present some phenotypes similar to DMD, such as a decrease in the size and number of myofibers accompanied by an increase in fragmented fibers [44–47].