Long-term positive energy balance that results in exssive accumulation of lipids is associated with a constellation of metabolic and pathphysologic abnormalities including impaired insulin signaling and insulin resistance, lipotoxicity, dyslipidemia (high plasma TG and low HDL-cholesteral concentrations), hypertension, and low-grade systemic inflammation [7, 13, 36]. This evidence concerns the gene INS and Insulin resistance.