Interestingly, the results of colocalization analysis showed that S100A16 (coloc, PP.H4.abf = 0.933), S100A14 (coloc, PP.H4.abf = 0.913), and PDE5A (coloc, PP.H4.abf = 0.855) had the shared causal variation with HER-positive breast and colorectal cancers, respectively (Fig. 2). The gene discussed is PDE5A; the disease is colorectal cancer.