Additionally, death (PT: 10,011,906), dyspnoea (PT: 10,013,968), pleural effusion (PT: 10,035,598), blood albumin decreased (PT: 10,005,287), haemoptysis (PT: 10,018,964), and central nervous system lesion (PT: 10,051,290), might cause by the disease progression. This evidence concerns the gene ALB and Pleural effusion.