Multivariable logistic regression analysis was performed to adjust for potential confounding factors (tumour size, grade, anatomical site, performance status and histological subtype), which led to five proteins remaining significant between the two age groups (AYA: NDUFA9, SUCLA2, TUBB2B, MACROH2A2 and OA: CDK1). Here, MACROH2A2 is linked to neoplasm.