DKA is the most distressing complication of pump therapy, reported to be associated with lower socioeconomic status [16], and mostly occurring due to insulin infusion set blockage, infusion site problems, and users delay in detection of those issues (e.g., misjudging prolonged hyperglycemia, prolonged suspension of insulin basal rate for physical activities) [12, 13]. This evidence concerns the gene INS and Hyperglycemia.