If one would like to further explore the food intake or obesity-related effects of selective LH chemogenetic inhibition, it would be a logical next step to try to investigate the effectiveness of other virus serotypes (e.g., AAV2 or AAV8), and perhaps to try to reduce the affected brain area size by decreasing the applied virus volume (< 1000 nL) and/or the virus titer (< 1012 vg/ml). Here, PLOD1 is linked to obesity due to melanocortin 4 receptor deficiency.