These annotations also revealed that PML-RARA-carrying APL samples (n = 8) are dominated by GMPs are sensitive for Venetoclax, whereas AML with CBFB-MYH11 (n = 7) had the best fit (R2 = 0.78, P = 0.009) (Fig. 3c), although the small sample size of CBFB-MYH11 cases prohibits drawing robust conclusions. This evidence concerns the gene MYH11 and acute myeloid leukemia.