For example, the methylation status of MGMT and other genes was investigated in a cohort of 28 glioblastoma patients treated with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide plus cisplatin, and compared to tissue, the sensitivity for detecting MGMT methylation in serum was 62.5%, with a specificity of 92.3%41. Here, MGMT is linked to glioblastoma.