EMT has been recognized as a key factor in the promotion of tumor metastasis, IL-1β and transforming growth factor β2 (TGF-β2) have been found to decrease epithelial cell markers and increase mesenchymal cell markers in normal human esophageal microvessel endothelial cells, enhancing cell proliferation and migration properties [30]. This evidence concerns the gene TGFB2 and neoplasm.