Similarly, we observed increased CCL2/MCP-1 levels in BALF with endothelial overexpression of Sparcl1 (Fig. 3M and Supplementary Fig. 7E), but no significant changes of CCL2 in serum (Supplementary Fig. 7F), and no differences in viral load in the lungs during infection (Supplementary Fig. 7G). Here, CCL2 is linked to infection.