We observed significantly increased M1_like and decreased M2_like macrophage populations in ECSparcl1-OE mice compared with WT mice on day 20 post influenza infection, both in total MΦ (CD64+F4/80+) as well as specifically within AMs and I/RMs (Fig. 4A–C, Supplementary Fig. 11A). The gene discussed is FCGR1A; the disease is influenza.