CD274 and colonic neoplasm: In the study conducted by the Xu lab using a mouse model of colon cancer, the cysteine residue at position 272 (Cys272) of the PD-L1 protein is palmitoylated by the palmitoyltransferase DHHC3 (aspartate-histidine-histidine-cysteine 3), thereby inhibiting the ubiquitination and degradation of PD-L1 and increasing PD-L1 expression levels.