LINC01140 directly inhibits miR-377-3p and miR-155-5p expression levels by sponging, and both miR-377-3p and miR-155-5p directly bind to PD-L1 3′-UTR, which leads to upregulation of the downstream target PD-L1 and promotes proliferation, migration and invasion of lung cancer cells [254]. Here, CD274 is linked to lung carcinoma.