Secondly, IFITM4P acts as a scaffold in the cytoplasm, recruiting SASH1 to bind and phosphorylate TAK1 (Thr187), thereby promoting phosphorylation of NF-κB (Ser536) and concomitantly inducing PD-L1 expression, inhibiting tumor immune responses [256]. Here, NFKB1 is linked to neoplasm.