In hepatocellular carcinoma cells, tumor-specific SLFN11 inhibits hepatocellular carcinoma proliferation and metastasis, knockdown of SLFN11 in HCC cells promotes macrophage migration and polarization towards the M2 phenotype in a CCL2 cytokine-dependent manner, thereby activating the NF-κB pathway, upregulating the expression of PD-L1 and accelerating tumor progression. This evidence concerns the gene SLFN11 and hepatocellular carcinoma.