In colorectal cancer and melanoma, defects in METTL3 or METTL14 promote IFN-γ-Stat1-Irf1 signaling by stabilizing STAT1 and IRF1 mRNA expression in an m6A-YTHDF2-dependent manner, thus upregulating PD-L1 expression and making tumors more sensitive to PD-L1 [266]. Here, IRF1 is linked to melanoma.